On the basis of the complex structure, large differences in wall thickness, and stringent material technology requirements of wheel hubs, rational casting and isothermal quenching heat treatment processes for the production of high-quality wheel hub castings are necessary. In this study, the appropriate pouring position and parting surface were determined, followed by the design of the sand core, pattern layout, and gating system. To meet the hardness requirements in different parts of the wheel hub, the gear hole in the center of the wheel hub is designed as a non-cast hole (machining into a gear hole after heat treatment), and the holding time of isothermal quenching is shortened; that is, after 900 ℃×2 h austenitization, it is subjected to 280 ℃×35 min isothermal quenching treatment in a nitrate pool. The developed wheel hub casting has good appearance quality, and no obvious casting defects such as shrinkage cavities, porosity, inclusions, and gas pores have been found.