Focusing on a Ti-62222 titanium alloy, the deformation behavior and evolution of the microstructure during hot compression were investigated. The results indicate that the true stress-true strain curve of the Ti-62222 titanium alloy generally exhibits strain softening, with a peak appearing at a low strain, followed by a decrease in the flow stress as the strain increases. The flow stress increases with increasing strain rate and decreasing deformation temperature. Research on the hot deformation microstructure reveals that as the temperature rises, the content of the α phase in the alloy decreases, whereas the content of the β phase increases, and the globularization rate of the α phase increases. Under conditions of large deformation, the content of the α phase is negatively correlated with the deformation amount, meaning that the greater the deformation is, the lower the content of the α phase. The globularization rate of the α phase significantly increases with increasing deformation amount. When the strain rate is high, the content of the α phase decreases with increasing strain rate. The strain rate has an inhibitory effect on the globularization of the lamellar α phase, and the globularization rate decreases as the strain rate increases.