Laser-directed energy deposition (LDED) of Ti alloys has many advantages, such as high efficiency and high material utilisation, but its inherent characteristics, such as a large cooling rate and temperature gradient, make LDED Ti alloys prone to anisotropy. Therefore, it is necessary to study the microstructure in different planes and the mechanical properties in different directions of LDED Ti alloys. In this paper, a Ti-6Al alloy was selected as the object of investigation. The phases, microstructures, and grain characteristics of the LDED Ti-6Al alloys were characterised via optical microscopye (OM), X-ray diffraction (XRD), scanning electron microscopye (SEM) and electron backscattering diffraction (EBSD). The results show that there is only a single α-phase (HCP structure) in the alloy. The Ti-6Al alloy exhibits different microstructural features at different heights, i.e., along the building direction, the bottom is composed of fine equiaxed grains, the middle is composed of columnar grains, and the top is composed of equiaxed/subequiaxed grains. The smallest average grain size of 22.251 9 μm can be observed in the XOY plane; the largest grain size of 38.940 8 μm is present in the YOZ plane. Among the three different planes, the XOY plane has the highest low-angle grain boundaries (LAGBs) volume fraction of 19.5%, whereas the YOZ plane has the lowest LAGBs volume fraction of 12.2%. The highest tensile strength of 669.94 MPa, with a corresponding elongation of 13.9%, is observed along the Z direction, i.e., parallel to the building direction. In the X direction, the elongation is the lowest (11.4%), and the corresponding tensile strength is 560.55 MPa.