Ti-Zr-Nb-Mo alloys with different compositions were prepared by vacuum melting furnace. The microstructure and properties of the alloy were studied by means of optical microscope (OM), X-ray diffractometer (XRD), universal testing machine and electrochemical workstation. The results show that with the increase of Mo content, the as-cast Ti-Zr-Nb-Mo alloy is a single β phase, and the diffraction peak shifts to a higher angle, and the average grain size of the alloy decreases first and then increases. Among them, the average grain size of as-cast (TiZr)₈₀Nb₁₀Mo₁₀ alloy is the smallest. The yield strength and hardness of as-cast (TiZr)₇₅Nb₁₀Mo₁₅ alloy are the highest, 887 MPa and 471 HV, respectively, with the increase of Mo content. The corrosion resistance of as-cast (ZrTi)₈₀Nb₁₀Mo₁₀ alloy is good, self-corrosion potential and self-corrosion current density are -261.1 mV and 354.5 nA•cm^-2, respectively.